Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Evaluation of diclofenac emulgel prepared with sesame oil as a lipophilic carrier

Zwanden Sule Yahaya¹ , Latifat Oyiza Otaru¹, Boma Blessing Mohammed¹, Olutayo Ademola Adeleye², Na'anman Charles Dagogot³, Idris Abdullahi⁴

¹Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna; ²Department of Pharmaceutics and Pharmaceutical Technology, Federal University Oye-Ekiti, Oye-Ekiti; ³Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria; ⁴Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria.

For correspondence:- Zwanden Yahaya Email: zwanden.yahaya@kasu.edu.ng Tel:+2348060235790

Accepted: 8 October 2023 Published: 30 October 2023

Citation: Yahaya ZS, Otaru LO, Mohammed BB, Adeleye OA, Dagogot NC, Abdullahi I. Evaluation of diclofenac emulgel prepared with sesame oil as a lipophilic carrier. Trop J Pharm Res 2023; 22(10):2021-2027 doi: 10.4314/tjpr.v22i10.1

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation.

Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were evaluated for rheology, syneresis, Fourier transform infrared (FTIR) spectroscopy, spreadability, extrudability, and anti-inflammatory activity.

Results: Product characteristics of batches A2, A4, and A6 were not consistent with those of emulgels. Because Batch A1 showed characteristics that were the most stable, such as no pH changes, non-statistically significant changes (p = 1.000) in the viscosity results, and least spectrum changes following FTIR investigation, it was selected as the best batch. It showed similar anti-inflammatory activity when compared with commercially available diclofenac emulgel, giving a 50 % higher anti-inflammatory effect than aqueous diclofenac dispersion.

Conclusion: Sesame oil is a potential lipophilic component in emulgel formulations for topical delivery of hydrophobic drugs.

Keywords: Diclofenac, Emulgel, Ant-inflammatory, Sesame oil